The Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1 | Zendy

Nadine DyballaRukes | Zendy; Philipp Jakobs | Zendy; Anna Eckers | Zendy; Niloofar AleAgha | Zendy; Vlad Serbulea | Zendy; Karin Aufenvenne | Zendy; Tim-Christian Zschauer | Zendy; Lothar L. Rabanter | Zendy; Sascha Jakob | Zendy; Florian von Ameln | Zendy; Olaf Eckermann | Zendy; Norbert Leitinger | Zendy; Christine Goy | Zendy; Joachim Altschmied | Zendy; Judith Haendeler | Zendy

Open Access

The Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1

Author(s) -

Nadine DyballaRukes,

Philipp Jakobs,

Anna Eckers,

Niloofar AleAgha,

Vlad Serbulea,

Karin Aufenvenne,

Tim-Christian Zschauer,

Lothar L. Rabanter,

Sascha Jakob,

Florian von Ameln,

Olaf Eckermann,

Norbert Leitinger,

Christine Goy,

Joachim Altschmied,

Judith Haendeler

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6799

Subject(s) - apoptosis , thioredoxin , microbiology and biotechnology , biology , biochemistry , oxidative stress

The APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1) has a disordered N-terminus, a redox, and a DNA repair domain. APEX1 has anti-apoptotic properties, which have been linked to both domains depending on cell type and experimental conditions.

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