Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression | Zendy

Diana Klein | Zendy; Jennifer Steens | Zendy; Alina Wiesemann | Zendy; Florian Schulz | Zendy; Farnusch Kaschani | Zendy; Katharina Röck | Zendy; Masahiro Yamaguchi | Zendy; Florian Wirsdörfer | Zendy; Markus Kaiser | Zendy; Jens W. Fischer | Zendy; Martin Stuschke | Zendy; Verena Jendrossek | Zendy

Open Access

Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression

Author(s) -

Diana Klein,

Jennifer Steens,

Alina Wiesemann,

Florian Schulz,

Farnusch Kaschani,

Katharina Röck,

Masahiro Yamaguchi,

Florian Wirsdörfer,

Markus Kaiser,

Jens W. Fischer,

Martin Stuschke,

Verena Jendrossek

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6748

Subject(s) - mesenchymal stem cell , superoxide dismutase , sod1 , fibrosis , cancer research , stem cell , medicine , biology , pathology , microbiology and biotechnology , oxidative stress

Radiation-induced normal tissue toxicity is closely linked to endothelial cell (EC) damage and dysfunction (acute effects). However, the underlying mechanisms of radiation-induced adverse late effects with respect to the vascular compartment remain elusive, and no causative radioprotective treatment is available to date.

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