Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1 | Zendy

Di Shao | Zendy; Jingyan Han | Zendy; Xiuyun Hou | Zendy; Jessica Fry | Zendy; Jessica B. Behring | Zendy; Francesca Seta | Zendy; Michelle T. Long | Zendy; Hemant K. Roy | Zendy; Richard A. Cohen | Zendy; Reiko Matsui | Zendy; Markus Bachschmid | Zendy

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Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1

Author(s) -

Di Shao,

Jingyan Han,

Xiuyun Hou,

Jessica Fry,

Jessica B. Behring,

Francesca Seta,

Michelle T. Long,

Hemant K. Roy,

Richard A. Cohen,

Reiko Matsui,

Markus Bachschmid

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6716

Subject(s) - glutaredoxin , steatosis , steatohepatitis , lipid metabolism , fatty liver , sirtuin , biochemistry , biology , glutathione , medicine , endocrinology , nad+ kinase , enzyme , disease

Nonalcoholic fatty liver (NAFL) is a common liver disease associated with metabolic syndrome, obesity, and diabetes that is rising in prevalence worldwide. Various molecular perturbations of key regulators and enzymes in hepatic lipid metabolism cause NAFL. However, redox regulation through glutathione (GSH) adducts in NAFL remains largely elusive. Glutaredoxin-1 (Glrx) is a small thioltransferase that removes protein GSH adducts without having direct antioxidant properties. The liver contains abundant Glrx but its metabolic function is unknown.

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