Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer | Zendy

Kateřina Rohlenová | Zendy; Karishma Sachaphibulkij | Zendy; Jan Štursa | Zendy; Ayenachew BezaworkGeleta | Zendy; Jan Blecha | Zendy; Berwini Endaya | Zendy; Lukáš Werner | Zendy; Jiří Černý | Zendy; Renata Zobalová | Zendy; Jacob Goodwin | Zendy; Tomáš Špaček | Zendy; Elham Alizadeh Pesdar | Zendy; Bing Yan | Zendy; Maria Nguyen | Zendy; Magdaléna Vondrusová | Zendy; Margaryta Sobol | Zendy; Petr Ježek | Zendy; Pavel Hozák | Zendy; Jaroslav Truksa | Zendy; Jakub Rohlena | Zendy; LanFeng Dong | Zendy; Jiřı́ Neužil | Zendy

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Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2^high Breast Cancer

Author(s) -

Kateřina Rohlenová,

Karishma Sachaphibulkij,

Jan Štursa,

Ayenachew BezaworkGeleta,

Jan Blecha,

Berwini Endaya,

Lukáš Werner,

Jiří Černý,

Renata Zobalová,

Jacob Goodwin,

Tomáš Špaček,

Elham Alizadeh Pesdar,

Bing Yan,

Maria Nguyen,

Magdaléna Vondrusová,

Margaryta Sobol,

Petr Ježek,

Pavel Hozák,

Jaroslav Truksa,

Jakub Rohlena,

LanFeng Dong,

Jiřı́ Neužil

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6677

Subject(s) - tamoxifen , in vivo , cancer research , in vitro , mitochondrion , biology , microbiology and biotechnology , respiratory chain , oncogene , reactive oxygen species , breast cancer , apoptosis , cancer , chemistry , pharmacology , cell cycle , biochemistry , genetics

Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to eliminate Her2 high disease.

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