Modulation of Pancreatic Islets' Function and Survival During Aging Involves the Differential Regulation of Endoplasmic Reticulum Stress by p21 and CHOP | Zendy

Chrysovalantou Mihailidou | Zendy; Ioulia Chatzistamou | Zendy; Athanasios G. Papavassiliou | Zendy; Hippokratis Kiaris | Zendy

Open Access

Modulation of Pancreatic Islets' Function and Survival During Aging Involves the Differential Regulation of Endoplasmic Reticulum Stress by p21 and CHOP

Author(s) -

Chrysovalantou Mihailidou,

Ioulia Chatzistamou,

Athanasios G. Papavassiliou,

Hippokratis Kiaris

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6671

Subject(s) - endoplasmic reticulum , chop , microbiology and biotechnology , function (biology) , stress (linguistics) , pancreatic islets , endocrinology , medicine , chemistry , islet , biology , insulin , linguistics , philosophy

Although endoplasmic reticulum (ER) stress is recognized as a major mechanism causing pancreatic dysfunction in diabetes, little is known on how aging modulates the process. Here, we compared the response with ER stress, viability, and insulin release from pancreatic islets of young (6 weeks) or aged (14 months) mice.

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