Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK | Zendy

Sonia MartínezRevelles | Zendy; Ana B. GarcíaRedondo | Zendy; María Soledad Avendaño | Zendy; Saray Varona | Zendy; Teresa Palao | Zendy; Mar Orriols | Zendy; Fernanda Roberta Roque | Zendy; Ana Fortuño | Zendy; Rhian M. Touyz | Zendy; José MartínezGonzález | Zendy; Mercedes Salaíces | Zendy; Cristina Rodrı́guez | Zendy; Ana M. Briones | Zendy

Open Access

Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK

Author(s) -

Sonia MartínezRevelles,

Ana B. GarcíaRedondo,

María Soledad Avendaño,

Saray Varona,

Teresa Palao,

Mar Orriols,

Fernanda Roberta Roque,

Ana Fortuño,

Rhian M. Touyz,

José MartínezGonzález,

Mercedes Salaíces,

Cristina Rodrı́guez,

Ana M. Briones

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6642

Subject(s) - elastin , lysyl oxidase , oxidative stress , chemistry , reactive oxygen species , angiotensin ii , nadph oxidase , endocrinology , medicine , vascular smooth muscle , catalase , superoxide dismutase , apocynin , biochemistry , receptor , enzyme , pathology , smooth muscle

Vascular stiffness, structural elastin abnormalities, and increased oxidative stress are hallmarks of hypertension. Lysyl oxidase (LOX) is an elastin crosslinking enzyme that produces H 2 O 2 as a by-product. We addressed the interplay between LOX, oxidative stress, vessel stiffness, and elastin.

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