Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease | Zendy

Olga Gorelenkova Miller | Zendy; Jessica B. Behring | Zendy; Sandra L. Siedlak | Zendy; Sirui Jiang | Zendy; Reiko Matsui | Zendy; Markus Bachschmid | Zendy; Xiongwei Zhu | Zendy; John J. Mieyal | Zendy

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Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease

Author(s) -

Olga Gorelenkova Miller,

Jessica B. Behring,

Sandra L. Siedlak,

Sirui Jiang,

Reiko Matsui,

Markus Bachschmid,

Xiongwei Zhu,

John J. Mieyal

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6598

Subject(s) - downregulation and upregulation , neuroinflammation , microglia , proinflammatory cytokine , neurodegeneration , tumor necrosis factor alpha , biology , microbiology and biotechnology , immunology , inflammation , medicine , biochemistry , disease , gene

Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts, including diabetes. In this study, we investigated the potential impact of Grx1 upregulation in the central nervous system on dopaminergic (DA) viability.

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