Cytosolic NADH-NAD+Redox Visualized in Brain Slices by Two-Photon Fluorescence Lifetime Biosensor Imaging | Zendy

Rebecca Mongeon | Zendy; Veena Venkatachalam | Zendy; Gary Yellen | Zendy

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Cytosolic NADH-NAD⁺Redox Visualized in Brain Slices by Two-Photon Fluorescence Lifetime Biosensor Imaging

Author(s) -

Rebecca Mongeon,

Veena Venkatachalam,

Gary Yellen

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6593

Subject(s) - nad+ kinase , fluorescence , redox , cytosol , biosensor , chemistry , two photon excitation microscopy , biophysics , biochemistry , photochemistry , nuclear magnetic resonance , biology , enzyme , physics , optics , inorganic chemistry

Cytosolic NADH-NAD(+) redox state is central to cellular metabolism and a valuable indicator of glucose and lactate metabolism in living cells. Here we sought to quantitatively determine NADH-NAD(+) redox in live cells and brain tissue using a fluorescence lifetime imaging of the genetically-encoded single-fluorophore biosensor Peredox.

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