The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress | Zendy

Mei Xin | Zendy; Antoine Chaffiol | Zendy; Christo Kole | Zendy; Ying Yang | Zendy; Géraldine Millet-Puel | Zendy; Emmanuelle Clérin | Zendy; Najate Aït-Ali | Zendy; Jean Bennett | Zendy; Deniz Dalkara | Zendy; JoséAlain Sahel | Zendy; Jens Duebel | Zendy; Thierry Léveillard | Zendy

Open Access

The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress

Author(s) -

Mei Xin,

Antoine Chaffiol,

Christo Kole,

Ying Yang,

Géraldine Millet-Puel,

Emmanuelle Clérin,

Najate Aït-Ali,

Jean Bennett,

Deniz Dalkara,

JoséAlain Sahel,

Jens Duebel,

Thierry Léveillard

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6509

Subject(s) - retinitis pigmentosa , biology , microbiology and biotechnology , genetics , pedf , oxidative stress , retinal degeneration , gene , biochemistry , angiogenesis

Rod-derived cone viability factor long (RdCVFL) is an enzymatically active thioredoxin encoded by the nucleoredoxin-like-1 (Nxnl1) gene. The second product of the gene, RdCVF, made by alternative splicing is a novel trophic factor secreted by rods that protects cones in rodent models of retinitis pigmentosa, the most prevalent inherited retinal disease. It acts on cones by stimulating aerobic glycolysis through its interaction with a complex containing basigin-1 and the glucose transporter GLUT1. We studied the role of Nxnl1 in cones after its homologous recombination using a transgenic line expressing Cre recombinase under the control of a cone opsin promoter.

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