Carbon Monoxide Gas Is Not Inert, but Global, in Its Consequences for Bacterial Gene Expression, Iron Acquisition, and Antibiotic Resistance | Zendy

Lauren K. Wareham | Zendy; Ronald Begg | Zendy; Helen E. Jesse | Zendy; Johan W. A. van Beilen | Zendy; Salar Ibrahim Ali | Zendy; Dimitri A. Svistunenko | Zendy; Samantha McLean | Zendy; Klaas J. Hellingwerf | Zendy; Guido Sanguinetti | Zendy; Robert K. Poole | Zendy

Open Access

Carbon Monoxide Gas Is Not Inert, but Global, in Its Consequences for Bacterial Gene Expression, Iron Acquisition, and Antibiotic Resistance

Author(s) -

Lauren K. Wareham,

Ronald Begg,

Helen E. Jesse,

Johan W. A. van Beilen,

Salar Ibrahim Ali,

Dimitri A. Svistunenko,

Samantha McLean,

Klaas J. Hellingwerf,

Guido Sanguinetti,

Robert K. Poole

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6501

Subject(s) - heme , heme oxygenase , biochemistry , biology , carbon monoxide , gene expression , bacteria , chemistry , gene , enzyme , genetics , catalysis

Carbon monoxide is a respiratory poison and gaseous signaling molecule. Although CO-releasing molecules (CORMs) deliver CO with temporal and spatial specificity in mammals, and are proven antimicrobial agents, we do not understand the modes of CO toxicity. Our aim was to explore the impact of CO gas per se, without intervention of CORMs, on bacterial physiology and gene expression.

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