Studies of Hematopoietic Cell Differentiation with a Ratiometric and Reversible Sensor of Mitochondrial Reactive Oxygen Species | Zendy

Amandeep Kaur | Zendy; Karolina Jankowska | Zendy; Chelsea Pilgrim | Zendy; Stuart T. Fraser | Zendy; Elizabeth J. New | Zendy

Open Access

Studies of Hematopoietic Cell Differentiation with a Ratiometric and Reversible Sensor of Mitochondrial Reactive Oxygen Species

Author(s) -

Amandeep Kaur,

Karolina Jankowska,

Chelsea Pilgrim,

Stuart T. Fraser,

Elizabeth J. New

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6495

Subject(s) - reactive oxygen species , redox , microbiology and biotechnology , mitochondrion , mitochondrial ros , biophysics , reactive nitrogen species , biology , chemistry , oxidative stress , biochemistry , organic chemistry

Chronic elevations in cellular redox state are known to result in the onset of various pathological conditions, but transient increases in reactive oxygen species (ROS)/reactive nitrogen species (RNS) are necessary for signal transduction and various physiological functions. There is a distinct lack of reversible fluorescent tools that can aid in studying and unraveling the roles of ROS/RNS in physiology and pathology by monitoring the variations in cellular ROS levels over time. In this work, we report the development of ratiometric fluorescent sensors that reversibly respond to changes in mitochondrial redox state.

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