Targeted Nitric Oxide Delivery by Supramolecular Nanofibers for the Prevention of Restenosis After Arterial Injury | Zendy

Edward Moreira Bahnson | Zendy; Hussein A. Kassam | Zendy; Tyson J. Moyer | Zendy; Wulin Jiang | Zendy; Courtney E. Morgan | Zendy; Janet M. Vercammen | Zendy; Qun Jiang | Zendy; Megan Flynn | Zendy; Samuel I. Stupp | Zendy; Melina R. Kibbe | Zendy

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Targeted Nitric Oxide Delivery by Supramolecular Nanofibers for the Prevention of Restenosis After Arterial Injury

Author(s) -

Edward Moreira Bahnson,

Hussein A. Kassam,

Tyson J. Moyer,

Wulin Jiang,

Courtney E. Morgan,

Janet M. Vercammen,

Qun Jiang,

Megan Flynn,

Samuel I. Stupp,

Melina R. Kibbe

Publication year - 2015

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6363

Subject(s) - neointimal hyperplasia , restenosis , nanofiber , medicine , nitric oxide , neointima , systemic administration , nanocarriers , pharmacology , in vivo , stent , nanotechnology , materials science , drug , biology , microbiology and biotechnology

Cardiovascular interventions continue to fail as a result of arterial restenosis secondary to neointimal hyperplasia. We sought to develop and evaluate a systemically delivered nanostructure targeted to the site of arterial injury to prevent neointimal hyperplasia. Nanostructures were based on self-assembling biodegradable molecules known as peptide amphiphiles. The targeting motif was a collagen-binding peptide, and the therapeutic moiety was added by S-nitrosylation of cysteine residues.

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