Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells | Zendy

Hye Jin Jin | Zendy; Hyang Ju Lee | Zendy; Jinbeom Heo | Zendy; Jisun Lim | Zendy; Miyeon Kim | Zendy; Min Kyung Kim | Zendy; Hae Yun Nam | Zendy; Gyong Hwa Hong | Zendy; You Sook Cho | Zendy; Soo Jin Choi | Zendy; In Gyu Kim | Zendy; DongMyung Shin | Zendy; Seong Who Kim | Zendy

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Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells

Author(s) -

Hye Jin Jin,

Hyang Ju Lee,

Jinbeom Heo,

Jisun Lim,

Miyeon Kim,

Min Kyung Kim,

Hae Yun Nam,

Gyong Hwa Hong,

You Sook Cho,

Soo Jin Choi,

In Gyu Kim,

DongMyung Shin,

Seong Who Kim

Publication year - 2015

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6359

Subject(s) - senescence , mesenchymal stem cell , paracrine signalling , biology , microbiology and biotechnology , phenotype , epigenetics , immunology , cancer research , receptor , genetics , gene

Cellular senescence and its secretory phenotype (senescence-associated secretory phenotype [SASP]) develop after long-term expansion of mesenchymal stromal cells (MSCs). Further investigation of this phenotype is required to improve the therapeutic efficacy of MSC-based cell therapies. In this study, we show that positive feedback between SASP and inherent senescence processes plays a crucial role in the senescence of umbilical cord blood-derived MSCs (UCB-MSCs).

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