Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes | Zendy

Hagir B. Suliman | Zendy; Fabio Zobi | Zendy; Claude A. Piantadosi | Zendy

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Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes

Author(s) -

Hagir B. Suliman,

Fabio Zobi,

Claude A. Piantadosi

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2015.6342

Subject(s) - microbiology and biotechnology , biology , mitochondrial biogenesis , heme oxygenase , transcription factor , tfam , cellular differentiation , nrf1 , mitochondrion , heme , biochemistry , gene , enzyme

The differentiation of embryonic stem (ES) cells into energetically efficient cardiomyocytes contributes to functional cardiac repair and is envisioned to ameliorate progressive degenerative cardiac diseases. Advanced cell maturation strategies are therefore needed to create abundant mature cardiomyocytes. In this study, we tested whether the redox-sensitive heme oxygenase-1/carbon monoxide (HO-1/CO) system, operating through mitochondrial biogenesis, acts as a mechanism for ES cell differentiation and cardiomyocyte maturation.

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