Hypoxia-Dependent Reactive Oxygen Species Signaling in the Pulmonary Circulation: Focus on Ion Channels | Zendy

Florian Veit | Zendy; Oleg Pak | Zendy; Ralf P. Brandes | Zendy; Norbert Weißmann | Zendy

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Hypoxia-Dependent Reactive Oxygen Species Signaling in the Pulmonary Circulation: Focus on Ion Channels

Author(s) -

Florian Veit,

Oleg Pak,

Ralf P. Brandes,

Norbert Weißmann

Publication year - 2014

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2014.6234

Subject(s) - hypoxic pulmonary vasoconstriction , hypoxia (environmental) , reactive oxygen species , redox , ion channel , microbiology and biotechnology , chemistry , trpc6 , signal transduction , gating , trpc1 , transient receptor potential channel , vasoconstriction , biophysics , biology , oxygen , medicine , biochemistry , receptor , organic chemistry

An acute lack of oxygen in the lung causes hypoxic pulmonary vasoconstriction, which optimizes gas exchange. In contrast, chronic hypoxia triggers a pathological vascular remodeling causing pulmonary hypertension, and ischemia can cause vascular damage culminating in lung edema.

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