Open AccessHypoxia-Dependent Reactive Oxygen Species Signaling in the Pulmonary Circulation: Focus on Ion Channels
Author(s) -
Florian Veit,
Oleg Pak,
Ralf P. Brandes,
Norbert Weißmann
Publication year - 2015
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2014.6234
Subject(s) - hypoxic pulmonary vasoconstriction , hypoxia (environmental) , reactive oxygen species , redox , ion channel , microbiology and biotechnology , chemistry , trpc6 , signal transduction , gating , trpc1 , transient receptor potential channel , vasoconstriction , biophysics , biology , oxygen , medicine , biochemistry , receptor , organic chemistry
An acute lack of oxygen in the lung causes hypoxic pulmonary vasoconstriction, which optimizes gas exchange. In contrast, chronic hypoxia triggers a pathological vascular remodeling causing pulmonary hypertension, and ischemia can cause vascular damage culminating in lung edema.