Open AccessInducible Glutamate Oxaloacetate Transaminase as a Therapeutic Target Against Ischemic Stroke
Author(s) -
Savita Khanna,
Zachary Briggs,
Cameron Rink
Publication year - 2015
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2014.6106
Subject(s) - penumbra , glutamate receptor , neuroprotection , excitotoxicity , neuroscience , stroke (engine) , pharmacology , biology , ischemia , medicine , biochemistry , mechanical engineering , receptor , engineering
Glutamate serves multi-faceted (patho)physiological functions in the central nervous system as the most abundant excitatory neurotransmitter and under pathological conditions as a potent neurotoxin. Regarding the latter, elevated extracellular glutamate is known to play a central role in ischemic stroke brain injury.