Protein Oxidation in Aging: Does It Play a Role in Aging Progression? | Zendy

Sandra Reeg | Zendy; Tilman Grune | Zendy

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Protein Oxidation in Aging: Does It Play a Role in Aging Progression?

Author(s) -

Sandra Reeg,

Tilman Grune

Publication year - 2014

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2014.6062

Subject(s) - lipofuscin , proteolysis , reactive oxygen species , protein aggregation , microbiology and biotechnology , proteasome , ageing , chemistry , redox , oxidative stress , apoptosis , protein degradation , biochemistry , biophysics , biology , enzyme , genetics , organic chemistry

A constant accumulation of oxidized proteins takes place during aging. Oxidation of proteins leads to a partial unfolding and, therefore, to aggregation. Protein aggregates impair the activity of cellular proteolytic systems (proteasomes, lysosomes), resulting in further accumulation of oxidized proteins. In addition, the accumulation of highly crosslinked protein aggregates leads to further oxidant formation, damage to macromolecules, and, finally, to apoptotic cell death. Furthermore, protein oxidation seems to play a role in the development of various age-related diseases, for example, neurodegenerative diseases.

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