Characterization of the Inflammatory Properties of Actively Released HMGB1 in Juvenile Idiopathic Arthritis | Zendy

Peter Lundbäck | Zendy; Pernilla Stridh | Zendy; Lena Klevenvall | Zendy; Rosalind E. Jenkins | Zendy; Marie Fischer | Zendy; Erik Sundberg | Zendy; Jan Andersson | Zendy; Daniel J. Antoine | Zendy; Helena Erlandsson Harris | Zendy

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Characterization of the Inflammatory Properties of Actively Released HMGB1 in Juvenile Idiopathic Arthritis

Author(s) -

Peter Lundbäck,

Pernilla Stridh,

Lena Klevenvall,

Rosalind E. Jenkins,

Marie Fischer,

Erik Sundberg,

Jan Andersson,

Daniel J. Antoine,

Helena Erlandsson Harris

Publication year - 2014

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2014.6039

Subject(s) - hmgb1 , gene isoform , inflammation , arthritis , chemistry , synovial fluid , immunology , biochemistry , medicine , osteoarthritis , pathology , alternative medicine , gene

Pathogenic effects of the endogenous inflammatory mediator high mobility group box protein 1 (HMGB1) have been described in several inflammatory diseases. Recent reports have underlined the importance of post-translational modifications (PTMs) in determination of HMGB1 function and release mechanisms. We investigated the occurrence of PTMs of HMGB1 obtained from synovial fluid (SF) of juvenile idiopathic arthritis (JIA) patients.

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