NADPH Oxidases in Vascular Pathology | Zendy

Anna Konior | Zendy; Agata Schramm | Zendy; Marta CześnikiewiczGuzik | Zendy; Tomasz J. Guzik | Zendy

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NADPH Oxidases in Vascular Pathology

Author(s) -

Anna Konior,

Agata Schramm,

Marta CześnikiewiczGuzik,

Tomasz J. Guzik

Publication year - 2013

Publication title -

antioxidants and redox signaling

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2013.5607

Subject(s) - nox1 , nox4 , nadph oxidase , nicotinamide adenine dinucleotide phosphate , xanthine oxidase , endothelial dysfunction , oxidative stress , biology , reactive oxygen species , nitric oxide synthase , inflammation , vascular tissue , peroxynitrite , vascular smooth muscle , microbiology and biotechnology , endothelium , vascular disease , nitric oxide , superoxide , endocrinology , biochemistry , medicine , oxidase test , immunology , enzyme , botany , smooth muscle

Reactive oxygen species (ROS) play a critical role in vascular disease. While there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases play a central role. They are a source of "kindling radicals," which affect other enzymes, such as nitric oxide synthase endothelial nitric oxide synthase or xanthine oxidase. This is important, as risk factors for atherosclerosis (hypertension, diabetes, hypercholesterolemia, and smoking) regulate the expression and activity of NADPH oxidases in the vessel wall.

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