Open AccessNADPH Oxidases in Vascular Pathology
Author(s) -
Anna Konior,
Agata Schramm,
Marta Cześnikiewicz-Guzik,
Tomasz J. Guzik
Publication year - 2014
Publication title -
antioxidants and redox signaling
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2013.5607
Subject(s) - nox1 , nox4 , nadph oxidase , nicotinamide adenine dinucleotide phosphate , xanthine oxidase , endothelial dysfunction , oxidative stress , biology , reactive oxygen species , nitric oxide synthase , inflammation , vascular tissue , peroxynitrite , vascular smooth muscle , microbiology and biotechnology , endothelium , vascular disease , nitric oxide , superoxide , endocrinology , biochemistry , medicine , oxidase test , immunology , enzyme , botany , smooth muscle
Reactive oxygen species (ROS) play a critical role in vascular disease. While there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases play a central role. They are a source of "kindling radicals," which affect other enzymes, such as nitric oxide synthase endothelial nitric oxide synthase or xanthine oxidase. This is important, as risk factors for atherosclerosis (hypertension, diabetes, hypercholesterolemia, and smoking) regulate the expression and activity of NADPH oxidases in the vessel wall.