Open AccessNitrosative Stress Induces Peroxiredoxin 1 Ubiquitination During Ischemic Insult via E6AP Activation in Endothelial Cells Both In Vitro and In Vivo
Author(s) -
Rongrong Tao,
Huan Wang,
Hong Li,
Jiayi Huang,
Ying Lu,
Mei Liao,
Wei Feng Ye,
Nan Lü,
Dan Zhu,
Qian Huang,
Kohji Fukunaga,
Yu Lou,
Ikuo Shoji,
Christopher S. Wilcox,
En Yin Lai,
Feng Han
Publication year - 2014
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2013.5381
Subject(s) - peroxynitrite , ubiquitin ligase , ubiquitin , microbiology and biotechnology , in vivo , reactive nitrogen species , nitrotyrosine , oxidative stress , downregulation and upregulation , chemistry , ischemia , endothelial dysfunction , reactive oxygen species , biology , nitric oxide , medicine , nitric oxide synthase , biochemistry , endocrinology , gene , enzyme , superoxide
Although there is accumulating evidence that increased formation of reactive nitrogen species in cerebral vasculature contributes to the progression of ischemic damage, but the underlying molecular mechanisms remain elusive. Peroxiredoxin 1 (Prx1) can initiate the antioxidant response by scavenging free radicals. Therefore, we tested the hypothesis that Prx1 regulates the susceptibility to nitrosative stress damage during cerebral ischemia in vitro and in vivo.