Open AccessPeroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model
Author(s) -
Atsunori Nabeshima,
Sohsuke Yamada,
Xin Guo,
Akihide Tanimoto,
Ke-Yong Wang,
Shohei Shimajiri,
Satoshi Kimura,
Takashi Tasaki,
Hirotsugu Noguchi,
Shohei Kitada,
Teruo Watanabe,
Junichi Fujii,
Kimitoshi Kohno,
Yasuyuki Sasaguri
Publication year - 2013
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2012.4946
Subject(s) - nonalcoholic steatohepatitis , type 2 diabetes , diabetes mellitus , type 1 diabetes , biology , medicine , endocrinology , immunology , nonalcoholic fatty liver disease , disease , fatty liver
Consumption of a high-fructose diet (HFrD) can induce the development of a metabolic syndrome, manifesting as nonalcoholic steatohepatitis (NASH) and/or type 2 diabetes mellitus (T2DM), via a process in which oxidative stress plays a critical role. Peroxiredoxin 4 (PRDX4) is a unique and only known secretory member of the PRDX antioxidant family. However, its putative roles in the development of NASH and/or T2DM have not been investigated.