Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model | Zendy

Atsunori Nabeshima | Zendy; Sohsuke Yamada | Zendy; Xin Guo | Zendy; Akihide Tanimoto | Zendy; KeYong Wang | Zendy; Shohei Shimajiri | Zendy; Satoshi Kimura | Zendy; Takashi Tasaki | Zendy; Hirotsugu Noguchi | Zendy; Shohei Kitada | Zendy; Teruo Watanabe | Zendy; Junichi Fujii | Zendy; Kimitoshi Kohno | Zendy; Yasuyuki Sasaguri | Zendy

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Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model

Author(s) -

Atsunori Nabeshima,

Sohsuke Yamada,

Xin Guo,

Akihide Tanimoto,

KeYong Wang,

Shohei Shimajiri,

Satoshi Kimura,

Takashi Tasaki,

Hirotsugu Noguchi,

Shohei Kitada,

Teruo Watanabe,

Junichi Fujii,

Kimitoshi Kohno,

Yasuyuki Sasaguri

Publication year - 2013

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2012.4946

Subject(s) - nonalcoholic steatohepatitis , type 2 diabetes , diabetes mellitus , type 1 diabetes , biology , medicine , endocrinology , immunology , nonalcoholic fatty liver disease , disease , fatty liver

Consumption of a high-fructose diet (HFrD) can induce the development of a metabolic syndrome, manifesting as nonalcoholic steatohepatitis (NASH) and/or type 2 diabetes mellitus (T2DM), via a process in which oxidative stress plays a critical role. Peroxiredoxin 4 (PRDX4) is a unique and only known secretory member of the PRDX antioxidant family. However, its putative roles in the development of NASH and/or T2DM have not been investigated.

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