Open AccessOxidation of the Yeast Mitochondrial Thioredoxin Promotes Cell Death
Author(s) -
Darren Greetham,
Paraskevi Kritsiligkou,
Rachel H. Watkins,
Zorana Carter,
Jill Parkin,
Chris M. Grant
Publication year - 2013
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2012.4597
Subject(s) - thioredoxin , programmed cell death , peroxiredoxin , mitochondrion , thioredoxin reductase , oxidative stress , microbiology and biotechnology , mitochondrial ros , reactive oxygen species , biology , apoptosis , biochemistry , chemistry , enzyme , peroxidase
Yeast, like other eukaryotes, contains a complete mitochondrial thioredoxin system comprising a thioredoxin (Trx3) and a thioredoxin reductase (Trr2). Mitochondria are a main source of reactive oxygen species (ROS) in eukaryotic organisms, and this study investigates the role of Trx3 in regulating cell death during oxidative stress conditions.