The Use and Abuse of Heme in Apicomplexan Parasites | Zendy

Giel G. van Dooren | Zendy; Alexander T. Kennedy | Zendy; Geoffrey I. McFadden | Zendy

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The Use and Abuse of Heme in Apicomplexan Parasites

Author(s) -

Giel G. van Dooren,

Alexander T. Kennedy,

Geoffrey I. McFadden

Publication year - 2012

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2012.4539

Subject(s) - heme , biology , apicomplexa , intracellular , biochemistry , intracellular parasite , microbiology and biotechnology , plasmodium falciparum , malaria , enzyme , immunology

Heme is an essential prosthetic group for most life on Earth. It functions in numerous cellular redox reactions, including in antioxidant defenses and at several stages of the electron transport chain in prokaryotes and eukaryotic mitochondria. Heme also functions as a sensor and transport molecule for gases such as oxygen. Heme is a complex organic molecule and can only be synthesized through a multienzyme pathway from simpler precursors. Most free-living organisms synthesize their own heme by a broadly conserved metabolic pathway. Parasites are adept at scavenging molecules from their hosts, and heme is no exception.

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