Open AccessWarburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis
Author(s) -
Stephanos Pavlides,
Iset Medina Vera,
Ricardo Gândara,
Sharon Sneddon,
Richard G. Pestell,
Isabelle Le Mercier,
Ubaldo MartinezOutschoorn,
Diana WhitakerMenezes,
Anthony Howell,
Federica Sotgia,
Michael P. Lisanti
Publication year - 2012
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2011.4243
Subject(s) - anaerobic glycolysis , mitophagy , warburg effect , autophagy , cancer cell , cancer , glycolysis , oxidative stress , mitochondrion , tumor microenvironment , metastasis , microbiology and biotechnology , biology , chemistry , biochemistry , cancer research , metabolism , genetics , apoptosis
Here, we review certain recent advances in oxidative stress and tumor metabolism, which are related to understanding the contributions of the microenvironment in promoting tumor growth and metastasis. In the early 1920s, Otto Warburg, a Nobel Laureate, formulated a hypothesis to explain the "fundamental basis" of cancer, based on his observations that tumors displayed a metabolic shift toward glycolysis. In 1963, Christian de Duve, another Nobel Laureate, first coined the phrase auto-phagy, derived from the Greek words "auto" and "phagy," meaning "self" and "eating."