Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and MetastasisviaOxidative Stress, Mitophagy, and Aerobic Glycolysis | Zendy

Stephanos Pavlides | Zendy; Iset Vera | Zendy; Ricardo Gândara | Zendy; Sharon Sneddon | Zendy; Richard G. Pestell | Zendy; Isabelle Le Mercier | Zendy; Ubaldo MartinezOutschoorn | Zendy; Diana WhitakerMenezes | Zendy; Anthony Howell | Zendy; Federica Sotgia | Zendy; Michael P. Lisanti | Zendy

Open Access

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and MetastasisviaOxidative Stress, Mitophagy, and Aerobic Glycolysis

Author(s) -

Stephanos Pavlides,

Iset Vera,

Ricardo Gândara,

Sharon Sneddon,

Richard G. Pestell,

Isabelle Le Mercier,

Ubaldo MartinezOutschoorn,

Diana WhitakerMenezes,

Anthony Howell,

Federica Sotgia,

Michael P. Lisanti

Publication year - 2011

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2011.4243

Subject(s) - mitophagy , autophagy , anaerobic glycolysis , warburg effect , glycolysis , oxidative stress , microbiology and biotechnology , metastasis , oxidative phosphorylation , chemistry , cancer research , cancer , biochemistry , biology , metabolism , genetics , apoptosis

Here, we review certain recent advances in oxidative stress and tumor metabolism, which are related to understanding the contributions of the microenvironment in promoting tumor growth and metastasis. In the early 1920s, Otto Warburg, a Nobel Laureate, formulated a hypothesis to explain the "fundamental basis" of cancer, based on his observations that tumors displayed a metabolic shift toward glycolysis. In 1963, Christian de Duve, another Nobel Laureate, first coined the phrase auto-phagy, derived from the Greek words "auto" and "phagy," meaning "self" and "eating."

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