Characterization of a Novel HIV-1 Recombinant Form (CRF01_AE/CRF07_BC/CRF08_BC) Identified from Guangxi, China | Zendy

Bingyu Liang | Zendy; Yao Yang | Zendy; Fei Zhang | Zendy; Kang Li | Zendy; Yuan Yang | Zendy; Weidong Ou | Zendy; Jiegang Huang | Zendy; Chuanyi Ning | Zendy; Li Ye | Zendy; Hao Liang | Zendy

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Characterization of a Novel HIV-1 Recombinant Form (CRF01_AE/CRF07_BC/CRF08_BC) Identified from Guangxi, China

Author(s) -

Bingyu Liang,

Yao Yang,

Fei Zhang,

Kang Li,

Yuan Yang,

Weidong Ou,

Jiegang Huang,

Chuanyi Ning,

Li Ye,

Hao Liang

Publication year - 2019

Publication title -

aids research and human retroviruses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.993

H-Index - 92

eISSN - 1931-8405

pISSN - 0889-2229

DOI - 10.1089/aid.2019.0185

Subject(s) - recombinant dna , virology , biology , phylogenetic tree , monophyly , population , human immunodeficiency virus (hiv) , gene , genetics , medicine , clade , environmental health

Recently, more and more kinds of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) were identified in the population in China. A novel HIV-1 recombinant virus (2016GXNNIDU016) was identified in this study, which was isolated from an HIV-1 infected intravenous drug user in Nanning, the capital of Guangxi, China. Phylogenetic analysis of the near full-length genome (NFLG) indicated that the sequence (2016GXNNIDU016) was a monophyletic branch that did not cluster with any previously identified genotype. Recombinant analysis showed that the NFLG of 2016GXNNIDU016 is composed of CRF07_BC, CRF01_AE, and CRF08_BC, including nine mosaic segments. Differing from previously documented CRF01_AE and CRF07/08_BC recombinant forms, 2016GXNNIDU016 increases the genetic complexity of HIV-1 in Guangxi. The constant emergence of novel recombinant forms should draw our attention to make more efforts in supervising and preventing the spread of HIV infection.

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