CD4–HIV-1 Envelope Interactions: Critical Insights for the Simian/HIV/Macaque Model | Zendy

Amit Sharma | Zendy; Julie Overbaugh | Zendy

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CD4–HIV-1 Envelope Interactions: Critical Insights for the Simian/HIV/Macaque Model

Author(s) -

Amit Sharma,

Julie Overbaugh

Publication year - 2018

Publication title -

aids research and human retroviruses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.993

H-Index - 92

eISSN - 1931-8405

pISSN - 0889-2229

DOI - 10.1089/aid.2018.0110

Subject(s) - virology , simian immunodeficiency virus , macaque , biology , simian , transmission (telecommunications) , human immunodeficiency virus (hiv) , aids vaccines , lentivirus , virus , immunology , viral disease , vaccine trial , computer science , neuroscience , telecommunications

The macaque models of HIV-1 infection have been a cornerstone of research on transmission, pathogenesis, and prevention. In particular, the infection of macaques with chimeric simian/HIV-1 viruses (SHIVs) is central to the vaccine development pipeline because SHIVs encode the key target of HIV-1-neutralizing antibodies, the HIV-1 envelope (env) protein. In this review, we highlight some of the recent studies that have improved our understanding of the CD4-HIV-1 env interaction, which are crucial for development of SHIV/macaque models of HIV-1 infection.

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