Short Communication: Preferential Killing of HIV Latently Infected CD4+T Cells by MALT1 Inhibitor | Zendy

Hongmei Li | Zendy; Hui He | Zendy; Leyi Gong | Zendy; Mingui Fu | Zendy; Tony T. Wang | Zendy

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Short Communication: Preferential Killing of HIV Latently Infected CD4⁺T Cells by MALT1 Inhibitor

Author(s) -

Hongmei Li,

Hui He,

Leyi Gong,

Mingui Fu,

Tony T. Wang

Publication year - 2016

Publication title -

aids research and human retroviruses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.993

H-Index - 92

eISSN - 1931-8405

pISSN - 0889-2229

DOI - 10.1089/aid.2015.0343

Subject(s) - virology , human immunodeficiency virus (hiv) , biology , lentivirus , viral disease

We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the protein kinase C agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s). Altogether, the combination of MI-2 and bryostatin 1 displays selective killing of HIV latently infected CD4(+) T cells.

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