Open AccessShort Communication: Preferential Killing of HIV Latently Infected CD4+T Cells by MALT1 Inhibitor
Author(s) -
Hongmei Li,
Hui He,
Leyi Gong,
Mingui Fu,
Tony T. Wang
Publication year - 2016
Publication title -
aids research and human retroviruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.993
H-Index - 92
eISSN - 1931-8405
pISSN - 0889-2229
DOI - 10.1089/aid.2015.0343
Subject(s) - virology , human immunodeficiency virus (hiv) , biology , lentivirus , viral disease
We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the protein kinase C agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s). Altogether, the combination of MI-2 and bryostatin 1 displays selective killing of HIV latently infected CD4(+) T cells.