Short Communication: Immune Activation Is Present in HIV-1-Exposed Seronegative Individuals and Is Independent of Microbial Translocation | Zendy

Irma Saulle | Zendy; Mara Biasin | Zendy; Federica Gnudi | Zendy; Veronica Rai | Zendy; Salomè V. Ibba | Zendy; Sergio Lo Caputo | Zendy; Francesco Mazzotta | Zendy; Daria Trabattoni | Zendy; Mario Clerici | Zendy

Open Access

Short Communication: Immune Activation Is Present in HIV-1-Exposed Seronegative Individuals and Is Independent of Microbial Translocation

Author(s) -

Irma Saulle,

Mara Biasin,

Federica Gnudi,

Veronica Rai,

Salomè V. Ibba,

Sergio Lo Caputo,

Francesco Mazzotta,

Daria Trabattoni,

Mario Clerici

Publication year - 2015

Publication title -

aids research and human retroviruses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.993

H-Index - 92

eISSN - 1931-8405

pISSN - 0889-2229

DOI - 10.1089/aid.2015.0019

Subject(s) - immune system , biology , chromosomal translocation , immunology , lipopolysaccharide , phenotype , human immunodeficiency virus (hiv) , virus , innate immune system , gene , genetics

Analyses of immune activation in HIV-exposed seronegative individuals (HESN) yielded discrepant results. To clarify this issue we performed an extensive investigation of immune parameters in HESN and, in particular, we analyzed in these individuals the possible presence of microbial translocation, the most widely accepted reason driving immune activation in HIV-infected patients. Results showed that immune activation, a skewing of T lymphocyte maturation, and increased responsiveness to lipopolysaccharide (LPS) characterize the HESN phenotype; this is not driven by alterations of the gastrointestinal barrier and microbial translocation. The activation state seen in HESN may influence the induction of stronger adaptive antiviral immune responses and may represent a virus exposure-induced innate immune protective phenotype against HIV.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research