A Novel Codon Insert in Protease of Clade B HIV Type 1 | Zendy

Parris S. Jordan | Zendy; Art F. Y. Poon | Zendy; Joseph J. Eron | Zendy; Kathleen Squires | Zendy; Caroline Ignacio | Zendy; Douglas D. Richman | Zendy; Davey M. Smith | Zendy

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A Novel Codon Insert in Protease of Clade B HIV Type 1

Author(s) -

Parris S. Jordan,

Art F. Y. Poon,

Joseph J. Eron,

Kathleen Squires,

Caroline Ignacio,

Douglas D. Richman,

Davey M. Smith

Publication year - 2009

Publication title -

aids research and human retroviruses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.993

H-Index - 92

eISSN - 1931-8405

pISSN - 0889-2229

DOI - 10.1089/aid.2008.0310

Subject(s) - insert (composites) , reverse transcriptase , codon usage bias , start codon , biology , virology , genetics , human immunodeficiency virus (hiv) , protease , coding region , stop codon , rna , gene , messenger rna , enzyme , genome , mechanical engineering , biochemistry , engineering

A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. A one codon insert was observed in the protease region between codon 40 and 41 simultaneously with a two codon insert present in the reverse transcriptase region at codon 69.

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