Open AccessNatural Polymorphisms of HIV Type 2polSequences from Drug-Naive Individuals
Author(s) -
Ricardo Parreira,
Filipa Monteiro,
Elizabeth Pádua,
J. Piedade,
Teresa Venenno,
Maria Teresa Paixão,
Aida Esteves
Publication year - 2006
Publication title -
aids research and human retroviruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.993
H-Index - 92
eISSN - 1931-8405
pISSN - 0889-2229
DOI - 10.1089/aid.2006.22.1178
Subject(s) - reverse transcriptase , protease , virology , biology , drug resistance , human immunodeficiency virus (hiv) , lentivirus , genotype , protease inhibitor (pharmacology) , drug naïve , coding region , hiv 1 protease , peptide sequence , drug , genetics , viral disease , polymerase chain reaction , gene , enzyme , viral load , antiretroviral therapy , pharmacology , biochemistry
Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored residues that have been associated with drug resistance in HIV-1-infected patients. In particular, the M46I substitution in the protease was detected in 90% of the sequences analyzed, which, together with the other substitutions identified, may indicate a reduced susceptibility of HIV-2-infected drug-naive patients to PI. Furthermore, interpretation of genotypic data with four available algorithms, developed for interpretation of HIV-1 sequence data, suggested nonoverlapping profiles of drug resistance.
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