Open AccessSynthesis, characterization and bioactivity of thio-acetamide modified ZnO nanoparticles embedded in zinc acetate matrix
Author(s) -
U. K. Panigrahi,
Basudeb Sahu,
Himadri Gourav Behuria,
Sumanta Kumar Sahu,
Soumyashree Dhal,
Shamima Hussain,
P. Mallick
Publication year - 2021
Publication title -
nano express
Language(s) - English
Resource type - Journals
ISSN - 2632-959X
DOI - 10.1088/2632-959x/abdad8
Subject(s) - acetamide , zinc , thio , nanoparticle , wurtzite crystal structure , nuclear chemistry , matrix (chemical analysis) , chemistry , materials science , organic chemistry , nanotechnology , chromatography
ZnO nanoparticles embedded in zinc acetate matrix were synthesized by chemical route. The effect of thio-acetamide concentration during its synthesis was probed by structural, morphological, optical and bioactivity studies. XRD characterization indicated the formation of dominant phase of zinc acetate along with the low intensity peak of wurtzite ZnO. Morphological transition from bulky-like feature to flower-like feature via flake-like feature, is evidenced with increasing thio-acetamide molar concentrations. The optical band gap of samples decreased from ∼3.29 to 3.24 eV whereas the emitted color shifted from near green to blue region with increasing of molar concentration of thio-acetamide from 0 to 30% in the sample. The nanoparticles exhibited antimicrobial activity against seven (7) common human pathogenic bacteria including drug resistant varieties K . pneumonaie and S. aureus . The nanoparticles formed pores in the biological model membranes made from egg-phosphatidyl choline. Our study reveals that the thio-acetamide modified ZnO nanoparticles embedded in zinc acetate matrix could be used as potential drug lead to fight drug resistance against K . pneumoniae and S. aureus .