Open AccessRespiratory and Limb Muscle Dysfunction in Pulmonary Arterial Hypertension: A Role for Exercise Training?
Author(s) -
Panagiotou Marios,
Peacock Andrew J.,
Johnson Martin K.
Publication year - 2015
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1086/682431
Subject(s) - medicine , respiratory system , pathophysiology , cardiology , physical therapy , pulmonary hypertension , pulmonary rehabilitation , rehabilitation , physical medicine and rehabilitation , intensive care medicine
Respiratory and limb muscle dysfunction is emerging as an important pathophysiological abnormality in pulmonary arterial hypertension (PAH). Muscle abnormalities appear to occur frequently and promote dyspnea, fatigue, and exercise limitation in patients with PAH. Preliminary data suggest that targeted muscle training may be of benefit, although further evidence is required to consolidate these findings into specific recommendations for exercise training in patients with PAH. This article reviews the current evidence on prevalence, risk factors, and implications of respiratory and limb muscle dysfunction in patients with PAH. It also reviews the impact of exercise rehabilitation on morphologic, metabolic, and functional muscle profile and outcomes in PAH. Future research priorities are highlighted.