Open AccessMechanisms Regulating Endothelial Permeability
Author(s) -
Sukriti Sukriti,
Tauseef Mohammad,
Yazbeck Pascal,
Mehta Dolly
Publication year - 2014
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1086/677356
Subject(s) - adherens junction , intracellular , microbiology and biotechnology , medicine , tight junction , endothelium , cell junction , inflammation , vascular permeability , ve cadherin , edema , endothelial stem cell , pathology , immunology , cell , biology , cadherin , in vitro , biochemistry
The endothelial monolayer partitioning underlying tissue from blood components in the vessel wall maintains tissue fluid balance and host defense through dynamically opening intercellular junctions. Edemagenic agonists disrupt endothelial barrier function by signaling the opening of the intercellular junctions leading to the formation of protein‐rich edema in the interstitial tissue, a hallmark of tissue inflammation that, if left untreated, causes fatal diseases, such as acute respiratory distress syndrome. In this review, we discuss how intercellular junctions are maintained under normal conditions and after stimulation of endothelium with edemagenic agonists. We have focused on reviewing the new concepts dealing with the alteration of adherens junctions after inflammatory stimulus.