Open AccessEpigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series)
Author(s) -
Loscalzo Joseph,
Handy Diane E.
Publication year - 2014
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1086/675979
Subject(s) - epigenetics , dna methylation , histone , medicine , epigenesis , epigenetic regulation of neurogenesis , disease , genetics , computational biology , bioinformatics , dna , biology , gene expression , gene , chromatin remodeling , pathology
Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunities for novel strategies for disease prevention and treatment.