A Common Polymorphism in the Interleukin‐8 Gene Promoter Is Associated with an Increased Risk for RecurrentClostridium difficileInfection | Zendy

Kevin W. Garey | Zendy; ZhiDong Jiang | Zendy; Shashank S. Ghantoji | Zendy; Vincent H. Tam | Zendy; Vaneet Arora | Zendy; Herbert L. DuPont | Zendy

Open Access

A Common Polymorphism in the Interleukin‐8 Gene Promoter Is Associated with an Increased Risk for RecurrentClostridium difficileInfection

Author(s) -

Kevin W. Garey,

ZhiDong Jiang,

Shashank S. Ghantoji,

Vincent H. Tam,

Vaneet Arora,

Herbert L. DuPont

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/657398

Subject(s) - medicine , gastroenterology , genotype , single nucleotide polymorphism , univariate analysis , prospective cohort study , odds ratio , incidence (geometry) , immunology , multivariate analysis , gene , biology , genetics , physics , optics

Neutrophil recruitment coordinated by intestinal interleukin (IL)-8 secretion is a key component in the pathogenesis of Clostridium difficile infection (CDI). We hypothesized that a common single-nucleotide polymorphism (SNP) in the -251 region of the IL-8 gene promoter may be predictive of recurrent CDI.

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