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Neutrophil recruitment coordinated by intestinal interleukin (IL)-8 secretion is a key component in the pathogenesis of Clostridium difficile infection (CDI). We hypothesized that a common single-nucleotide polymorphism (SNP) in the -251 region of the IL-8 gene promoter may be predictive of recurrent CDI.

A Common Polymorphism in the Interleukin‐8 Gene Promoter Is Associated with an Increased Risk for RecurrentClostridium difficileInfection