Open AccessDynamic Coinfection with Multiple Viral Subtypes in Acute Hepatitis C
Author(s) -
Jennifer A. Smith,
Judith H. Aberle,
Vicki M. Fleming,
Péter Ferenci,
Emma C. Thomson,
Peter Karayiannis,
Angela R. McLean,
Heidemarie Holzmann,
Paul Klenerman
Publication year - 2010
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/657317
Subject(s) - coinfection , hypervariable region , virology , biology , hepatitis c virus , viral load , viral disease , virus , hepacivirus , immunology , antibody
Acute hepatitis C virus (HCV) infection is rarely studied, but virus sequence evolution and host-virus dynamics during this early stage may influence the outcome of infection. Hypervariable region 1 (HVR1) is genetically diverse and under selective pressure from the host immune response. We analyzed HVR1 evolution by frequent sampling of an acutely infected HCV cohort.