Complications of Tumor Necrosis Factor–α Blockade in Chronic Granulomatous Disease–Related Colitis | Zendy

Gülbû Uzel | Zendy; Jordan S. Orange | Zendy; Nina Poliak | Zendy; Beatriz E. Marciano | Zendy; Theo Heller | Zendy; Steven M. Holland | Zendy

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Complications of Tumor Necrosis Factor–α Blockade in Chronic Granulomatous Disease–Related Colitis

Author(s) -

Gülbû Uzel,

Jordan S. Orange,

Nina Poliak,

Beatriz E. Marciano,

Theo Heller,

Steven M. Holland

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/657308

Subject(s) - medicine , blockade , chronic granulomatous disease , granulomatous disease , necrosis , colitis , tumor necrosis factor alpha , pathology , disease , gastroenterology , immunology , receptor

Chronic granulomatous disease (CGD) is a genetic disorder of the phagocyte NADPH oxidase, which predisposes patients to infections and inflammatory complications, including severe colitis. Management of CGD colitis is a challenge because standard immunosuppressive therapy increases the risk of infection in already immunocompromised hosts.

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