Open AccessHuman Papillomavirus Type 16 Variants in Paired Enrollment and Follow‐up Cervical Samples: Implications for a Proper Understanding of Type‐Specific Persistent Infections
Author(s) -
Long Fu Xi,
Laura A. Koutsky,
Philip E. Castle,
Zoe R. Edelstein,
Ayaka Hulbert,
Mark Schiffman,
Nancy B. Kiviat
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/657083
Subject(s) - confidence interval , natural history , ascus (bryozoa) , human papillomavirus , prospective cohort study , medicine , papillomaviridae , cervical cancer , hpv infection , persistence (discontinuity) , biology , immunology , cancer , geotechnical engineering , engineering , botany , ascospore , spore
Prospective studies of the persistence of human papillomavirus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n = 60), a variant switch occurred in 2 of 11 who had evidence of intervening negativity for HPV-16, compared with 1 of 49 who consistently tested positive (P = .11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom