Mediators of Innate and Adaptive Immune Responses Differentially Affect Immune Restoration Disease Associated withMycobacterium tuberculosisin HIV Patients Beginning Antiretroviral Therapy
Author(s) -
Benjamin G. Oliver,
Julian Elliott,
Patricia Price,
Michael Phillips,
Vonthanak Saphonn,
Mean Chhi Vun,
John Kaldor,
David A. Cooper,
Martyn A. French
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/657082
Subject(s) - immune reconstitution inflammatory syndrome , tuberculosis , immunology , immune system , medicine , chemokine , mycobacterium tuberculosis , innate immune system , cxcl10 , acquired immune system , disease , ccl18 , antiretroviral therapy , virus , viral load , pathology
Initiation of antiretroviral therapy (ART) in human immunodeficiency virus patients with treated or unrecognized Mycobacterium tuberculosis infection may result in tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) or ART-associated tuberculosis (ART-TB), respectively. Both conditions appear to be immune restoration disease but their immunopathogenesis is not completely understood.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom