Class I HLA‐A*7401 Is Associated with Protection from HIV‐1 Acquisition and Disease Progression in Mbeya, Tanzania | Zendy

Rebecca N. Koehler | Zendy; Anne Walsh | Zendy; Elmar Saathoff | Zendy; Sodsai Tovanabutra | Zendy; Miguel A. Arroyo | Zendy; Jeffery R. Currier | Zendy; Leonard Maboko | Zendy; Michael Hoelsher | Zendy; Merlin L. Robb | Zendy; Nelson L. Michael | Zendy; F. E. McCutchan | Zendy; Jerome H. Kim | Zendy; Gustavo H. Kijak | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Class I HLA‐A*7401 Is Associated with Protection from HIV‐1 Acquisition and Disease Progression in Mbeya, Tanzania

Author(s) -

Rebecca N. Koehler,

Anne Walsh,

Elmar Saathoff,

Sodsai Tovanabutra,

Miguel A. Arroyo,

Jeffery R. Currier,

Leonard Maboko,

Michael Hoelsher,

Merlin L. Robb,

Nelson L. Michael,

F. E. McCutchan,

Jerome H. Kim,

Gustavo H. Kijak

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/656913

Subject(s) - tanzania , immunology , odds ratio , human leukocyte antigen , cohort , medicine , allele , linkage disequilibrium , confidence interval , biology , haplotype , genetics , antigen , environmental science , environmental planning , gene

Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV-1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P = .011) and with protection from CD4(+) cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P = .032) and men (OR, 0.15; 95% CI, 0.01-0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research