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Tumefactive Demyelination—An Unusual Neurological Presentation of HIV
Author(s) -
Alison Uriel,
Rachael Stow,
Leann Johnson,
Anoop Varma,
Daniel du Plessis,
F Gray,
Amit Herwadkar,
Jeremy Holland,
Penny Lewthwaite,
E. Brooks Wilkins
Publication year - 2010
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/656812
Subject(s) - medicine , brain biopsy , magnetic resonance imaging , pathology , human immunodeficiency virus (hiv) , presentation (obstetrics) , biopsy , radiology , virology
We describe 3 individuals infected with human immunodeficiency virus with unusual focal brain syndromes; magnetic resonance imaging revealed "open-ring" pattern space occupying lesions. After deterioration while the patients were receiving anti-Toxoplasma therapy, brain biopsy was performed, which revealed aggressive demyelination consistent with tumefactive demyelination. Treatment with high-dose steroids resulted in complete recovery in all cases.

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