Antiretroviral Adherence and Development of Drug Resistance Are the Strongest Predictors of Genital HIV‐1 Shedding among Women Initiating Treatment | Zendy

Susan M. Graham | Zendy; Linnet N. Masese | Zendy; Ruth Gitau | Zendy; Zahra JalalianLechak | Zendy; Barbra A. Richardson | Zendy; Norbert Peshu | Zendy; Kishor Mandaliya | Zendy; James Kiarie | Zendy; Walter Jaoko | Zendy; Jeckoniah NdinyaAchola | Zendy; Julie Overbaugh | Zendy; R. Scott McClelland | Zendy

Open Access

Antiretroviral Adherence and Development of Drug Resistance Are the Strongest Predictors of Genital HIV‐1 Shedding among Women Initiating Treatment

Author(s) -

Susan M. Graham,

Linnet N. Masese,

Ruth Gitau,

Zahra JalalianLechak,

Barbra A. Richardson,

Norbert Peshu,

Kishor Mandaliya,

James Kiarie,

Walter Jaoko,

Jeckoniah NdinyaAchola,

Julie Overbaugh,

R. Scott McClelland

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/656790

Subject(s) - sex organ , medicine , viral shedding , transmission (telecommunications) , drug resistance , human immunodeficiency virus (hiv) , hiv drug resistance , viral load , antiretroviral therapy , immunology , lentivirus , sexual transmission , virus , virology , viral disease , biology , genetics , microbiology and biotechnology , microbicide , electrical engineering , engineering

Persistent genital human immunodeficiency virus type 1 (HIV-1) shedding among women receiving antiretroviral therapy (ART) may present a transmission risk. We investigated the associations between genital HIV-1 suppression after ART initiation and adherence, resistance, pretreatment CD4 cell count, and hormonal contraceptive use. First-line ART was initiated in 102 women. Plasma and genital HIV-1 RNA levels were measured at months 0, 3, and 6. Adherence was a strong and consistent predictor of genital HIV-1 suppression (P < .001), whereas genotypic resistance was associated with higher vaginal HIV-1 RNA level at month 6 (P = .04). These results emphasize the importance of adherence to optimize the potential benefits of ART for reducing HIV-1 transmission risk.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research