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Recombinant human activated protein C (APC) improves survival of patients with severe sepsis; this beneficial effect is especially apparent in patients with pneumococcal pneumonia. The aim of this study was to determine the effect of APC treatment initiated after induction of pneumococcal pneumonia on pulmonary coagulation, inflammation, and survival, with or without concurrent antibiotic therapy.

Therapeutic Recombinant Murine Activated Protein C Attenuates Pulmonary Coagulopathy and Improves Survival in Murine Pneumococcal Pneumonia