High Levels of Antibody to Panton‐Valentine Leukocidin Are Not Associated with Resistance toStaphylococcus aureus–Associated Skin and Soft‐Tissue Infection | Zendy

Christina Hermos | Zendy; Pauline Yoong | Zendy; Gerald B. Pier | Zendy

Open Access

High Levels of Antibody to Panton‐Valentine Leukocidin Are Not Associated with Resistance toStaphylococcus aureus–Associated Skin and Soft‐Tissue Infection

Author(s) -

Christina Hermos,

Pauline Yoong,

Gerald B. Pier

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/656742

Subject(s) - leukocidin , panton–valentine leukocidin , staphylococcus aureus , microbiology and biotechnology , staphylococcal skin infections , medicine , antibody , virulence , toxin , pneumonia , pathogenesis , skin infection , methicillin resistant staphylococcus aureus , virology , immunology , biology , bacteria , gene , genetics , biochemistry

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) expressing Panton-Valentine leukocidin (PVL) causes severe skin and soft-tissue infection (SSTI), necrotizing pneumonia, and other invasive infections. The PVL toxin has been implicated as a virulence factor, and antibody to a component of this toxin is under investigation as a vaccine candidate. The role of PVL in pathogenesis remains controversial, and it is unknown whether human serum antibody to PVL modulates infection.

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