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Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) expressing Panton-Valentine leukocidin (PVL) causes severe skin and soft-tissue infection (SSTI), necrotizing pneumonia, and other invasive infections. The PVL toxin has been implicated as a virulence factor, and antibody to a component of this toxin is under investigation as a vaccine candidate. The role of PVL in pathogenesis remains controversial, and it is unknown whether human serum antibody to PVL modulates infection.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

High Levels of Antibody to Panton‐Valentine Leukocidin Are Not Associated with Resistance to<i>Staphylococcus aureus</i>–Associated Skin and Soft‐Tissue Infection

High Levels of Antibody to Panton‐Valentine Leukocidin Are Not Associated with Resistance toStaphylococcus aureus–Associated Skin and Soft‐Tissue Infection