Open AccessAIDS‐AssociatedCryptococcus neoformansandPenicillium marneffeiCoinfection: A Therapeutic Dilemma in Resource‐Limited Settings
Author(s) -
Thuy Le,
Tran Thi Hong Chau,
Ngo Thi Kim Cuc,
Pham Si Lam,
Tran Phu Manh Sieu,
Cecilia M. Shikuma,
Jeremy Day
Publication year - 2010
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/656685
Subject(s) - cryptococcus neoformans , penicillium marneffei , coinfection , medicine , itraconazole , cryptococcus , cryptococcosis , fluconazole , microbiology and biotechnology , immunology , biology , human immunodeficiency virus (hiv) , antifungal , dermatology
AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource‐limited settings. Itraconazole poorly penetrates the central nervous system, whereas fluconazole has poor activity against P. marneffei. We prospectively report management of 1 patient and retrospectively review 7 coinfection cases from Vietnam.
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