Improved Prediction of HIV‐1 Coreceptor Usage with Sequence Information from the Second Hypervariable Loop of gp120 | Zendy

Alexander Thielen | Zendy; Nadine Sichtig | Zendy; Rolf Kaiser | Zendy; Jeffrey C. F. Lam | Zendy; P. Richard Harrigan | Zendy; Thomas Lengauer | Zendy

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Improved Prediction of HIV‐1 Coreceptor Usage with Sequence Information from the Second Hypervariable Loop of gp120

Author(s) -

Alexander Thielen,

Nadine Sichtig,

Rolf Kaiser,

Jeffrey C. F. Lam,

P. Richard Harrigan,

Thomas Lengauer

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/656600

Subject(s) - v3 loop , hypervariable region , set (abstract data type) , data set , computational biology , computer science , loop (graph theory) , mutation , position (finance) , basis (linear algebra) , receiver operating characteristic , human immunodeficiency virus (hiv) , biology , artificial intelligence , mathematics , virology , genetics , combinatorics , machine learning , peptide sequence , gene , finance , economics , programming language , geometry

Human immunodeficiency virus type 1 (HIV‐1) uses the CD4 receptor and a coreceptor to gain cell entry. Coreceptor usage is mainly determined by the V3 loop of gp120. Therefore, coreceptor usage is currently inferred from the genotype on the basis of V3 alone. However, several mutations outside V3 have been repeatedly reported to influence coreceptor usage. In this study, the impact of the V2 loop on coreceptor usage prediction was analyzed.

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