The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T‐Lymphocyte Epitopes | Zendy

Jun Liu | Zendy; Yeping Sun | Zendy; Jianxun Qi | Zendy; Fuliang Chu | Zendy; Hao Wu | Zendy; Feng Gao | Zendy; Taisheng Li | Zendy; Jinghua Yan | Zendy; George F. Gao | Zendy

Open Access

The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T‐Lymphocyte Epitopes

Author(s) -

Jun Liu,

Yeping Sun,

Jianxun Qi,

Fuliang Chu,

Hao Wu,

Feng Gao,

Taisheng Li,

Jinghua Yan,

George F. Gao

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/656315

Subject(s) - epitope , immunogen , immunogenicity , biology , cytotoxic t cell , virology , cellular immunity , antigen , immune system , ctl* , peripheral blood mononuclear cell , coronavirus , immunology , antibody , monoclonal antibody , cd8 , medicine , in vitro , biochemistry , disease , covid-19 , pathology , infectious disease (medical specialty)

Severe acute respiratory syndrome coronavirus (SARS-CoV), which emerged with highly contagious and life-threatening characteristics in 2002, remains a potential risk for future outbreaks. Membrane (M) and envelope (E) proteins are major structural proteins of the SARS-CoV. The M protein has been determined as a protective antigen in humoral responses. However, its potential roles in stimulating cellular immunity remain elusive.

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