Inferring the Serotype Associated with Dengue Virus Infections on the Basis of Pre‐ and Postinfection Neutralizing Antibody Titers | Zendy

Willem G. van Panhuis | Zendy; Robert V. Gibbons | Zendy; Timothy P. Endy | Zendy; Alan L. Rothman | Zendy; A Srikiatkhachorn | Zendy; Ananda Nisalak | Zendy; Donald S. Burke | Zendy; Derek A. T. Cummings | Zendy

Open Access

Inferring the Serotype Associated with Dengue Virus Infections on the Basis of Pre‐ and Postinfection Neutralizing Antibody Titers

Author(s) -

Willem G. van Panhuis,

Robert V. Gibbons,

Timothy P. Endy,

Alan L. Rothman,

A Srikiatkhachorn,

Ananda Nisalak,

Donald S. Burke,

Derek A. T. Cummings

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/656141

Subject(s) - serotype , plaque reduction neutralization test , dengue virus , virology , seroconversion , dengue fever , viremia , medicine , dengue vaccine , biology , titer , immunology , virus

Currently, the only tests capable of determining the serotype associated with dengue virus (DENV) infection require sampling during the period of acute viremia. No test can accurately detect the serotype associated with past DENV infections. The standard assay for determination of serotype-specific antibody against DENV is the plaque reduction neutralization test (PRNT), although performance of this test continues to be evaluated.

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