Cohorts for the Study of HIV‐1–Exposed but Uninfected Individuals: Benefits and Limitations | Zendy

Rachel Horton | Zendy; Paul J. McLaren | Zendy; Keith R. Fowke | Zendy; Joshua Kimani | Zendy; T. Blake Ball | Zendy

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Cohorts for the Study of HIV‐1–Exposed but Uninfected Individuals: Benefits and Limitations

Author(s) -

Rachel Horton,

Paul J. McLaren,

Keith R. Fowke,

Joshua Kimani,

T. Blake Ball

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/655971

Subject(s) - human immunodeficiency virus (hiv) , immunology , environmental health , medicine , demography , biology , sociology

Since the late 1980s, with the first identification of individuals who were exposed to human immunodeficiency virus type 1 (HIV-1) yet remained uninfected, or "HIV-1-resistant" individuals, a large number of cohorts that include HIV-exposed seronegative (HESN) subjects have been identified globally for the purpose of investigating the genetic, immunologic, and environmental factors that may help alter susceptibility to HIV-1. In this article, in light of the recent International Symposium on Natural Immunity to HIV, we review the characteristics of different groups with respect to their relative risks and briefly summarize the known cohorts that include exposed uninfected subjects worldwide.

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