Mind the Gap: Lack of Association between KIR3DL1*004/HLA‐Bw4–Induced Natural Killer Cell Function and Protection from HIV Infection | Zendy

Matthew S. Parsons | Zendy; Salix Boulet | Zendy; Rujun Song | Zendy; Julie Bruneau | Zendy; Naglaa H. Shoukry | Zendy; JeanPierre Routy | Zendy; Christos Tsoukas | Zendy; Nicole F. Bernard | Zendy

Open Access

Mind the Gap: Lack of Association between KIR3DL1*004/HLA‐Bw4–Induced Natural Killer Cell Function and Protection from HIV Infection

Author(s) -

Matthew S. Parsons,

Salix Boulet,

Rujun Song,

Julie Bruneau,

Naglaa H. Shoukry,

JeanPierre Routy,

Christos Tsoukas,

Nicole F. Bernard

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/655966

Subject(s) - human leukocyte antigen , immunology , genotype , flow cytometry , biology , hla b antigens , virology , allele , gene , antigen , genetics

Several combinations of genes encoding KIR3DL1 alleles and their HLA‐Bw4 ligands have been linked with favorable outcomes upon exposure to or infection with human immunodeficiency virus (HIV). Some protective KIR3DL1/HLA‐Bw4 combinations confer elevated natural killer (NK) cell functional potential. The K562‐stimulated functionality of NK cells from KIR3DL1*004/HLA‐Bw4 and control genotype carriers was assessed by flow cytometry and found to be higher in KIR3DL1*004/HLA‐Bw4 carriers. However, a comparison of the frequency of this combined genotype among HIV‐exposed uninfected and HIV‐infected subjects revealed no between‐group differences. Thus, despite its ability to license NK cells, KIR3DL1*004/HLA‐Bw4 is not associated with a reduced risk of infection.

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